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Endotoxemia

MedGen UID:
138231
Concept ID:
C0376618
Disease or Syndrome
Synonym: Endotoxemias
SNOMED CT: Endotoxemia (371770009)

Definition

A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndotoxemia

Professional guidelines

PubMed

Foster DM, Kellum JA
Int J Mol Sci 2023 Nov 10;24(22) doi: 10.3390/ijms242216185. PMID: 38003374Free PMC Article
Laitano O, Leon LR, Roberts WO, Sawka MN
J Appl Physiol (1985) 2019 Nov 1;127(5):1338-1348. Epub 2019 Sep 23 doi: 10.1152/japplphysiol.00452.2019. PMID: 31545156
Ely PH
Clin Dermatol 2018 May-Jun;36(3):376-389. Epub 2018 Mar 28 doi: 10.1016/j.clindermatol.2018.03.011. PMID: 29908580

Recent clinical studies

Etiology

Rungratanawanich W, Lin Y, Wang X, Kawamoto T, Chidambaram SB, Song BJ
Redox Biol 2023 Feb;59:102577. Epub 2022 Dec 13 doi: 10.1016/j.redox.2022.102577. PMID: 36528936Free PMC Article
Violi F, Cammisotto V, Bartimoccia S, Pignatelli P, Carnevale R, Nocella C
Nat Rev Cardiol 2023 Jan;20(1):24-37. Epub 2022 Jul 15 doi: 10.1038/s41569-022-00737-2. PMID: 35840742Free PMC Article
Luo P, Zhang Q, Zhong TY, Chen JY, Zhang JZ, Tian Y, Zheng LH, Yang F, Dai LY, Zou C, Li ZJ, Liu JH, Wang JG
Mil Med Res 2022 May 20;9(1):22. doi: 10.1186/s40779-022-00381-4. PMID: 35596191Free PMC Article
Ma L, Ni Y, Wang Z, Tu W, Ni L, Zhuge F, Zheng A, Hu L, Zhao Y, Zheng L, Fu Z
Gut Microbes 2020 Nov 9;12(1):1-19. doi: 10.1080/19490976.2020.1832857. PMID: 33151120Free PMC Article
Guevara-Cruz M, Flores-López AG, Aguilar-López M, Sánchez-Tapia M, Medina-Vera I, Díaz D, Tovar AR, Torres N
J Am Heart Assoc 2019 Sep 3;8(17):e012401. Epub 2019 Aug 27 doi: 10.1161/JAHA.119.012401. PMID: 31451009Free PMC Article

Diagnosis

Foster DM, Kellum JA
Int J Mol Sci 2023 Nov 10;24(22) doi: 10.3390/ijms242216185. PMID: 38003374Free PMC Article
Fang J, Yu CH, Li XJ, Yao JM, Fang ZY, Yoon SH, Yu WY
Front Cell Infect Microbiol 2022;12:997018. Epub 2022 Nov 8 doi: 10.3389/fcimb.2022.997018. PMID: 36425787Free PMC Article
Kellum JA, Formeck CL, Kernan KF, Gómez H, Carcillo JA
Crit Care Clin 2022 Apr;38(2):195-211. doi: 10.1016/j.ccc.2021.11.013. PMID: 35369943
Di Tommaso N, Gasbarrini A, Ponziani FR
Int J Environ Res Public Health 2021 Dec 6;18(23) doi: 10.3390/ijerph182312836. PMID: 34886561Free PMC Article
Laitano O, Leon LR, Roberts WO, Sawka MN
J Appl Physiol (1985) 2019 Nov 1;127(5):1338-1348. Epub 2019 Sep 23 doi: 10.1152/japplphysiol.00452.2019. PMID: 31545156

Therapy

Zhang W, Lin H, Zou M, Yuan Q, Huang Z, Pan X, Zhang W
Front Immunol 2022;13:826889. Epub 2022 Feb 18 doi: 10.3389/fimmu.2022.826889. PMID: 35251010Free PMC Article
Beam A, Clinger E, Hao L
Nutrients 2021 Aug 15;13(8) doi: 10.3390/nu13082795. PMID: 34444955Free PMC Article
Mohammad S, Thiemermann C
Front Immunol 2020;11:594150. Epub 2021 Jan 11 doi: 10.3389/fimmu.2020.594150. PMID: 33505393Free PMC Article
Motiani KK, Collado MC, Eskelinen JJ, Virtanen KA, Löyttyniemi E, Salminen S, Nuutila P, Kalliokoski KK, Hannukainen JC
Med Sci Sports Exerc 2020 Jan;52(1):94-104. doi: 10.1249/MSS.0000000000002112. PMID: 31425383Free PMC Article
Dickson K, Lehmann C
Int J Mol Sci 2019 Sep 5;20(18) doi: 10.3390/ijms20184341. PMID: 31491842Free PMC Article

Prognosis

Bielka W, Przezak A, Pawlik A
Int J Mol Sci 2022 Jan 1;23(1) doi: 10.3390/ijms23010480. PMID: 35008906Free PMC Article
Laitano O, Leon LR, Roberts WO, Sawka MN
J Appl Physiol (1985) 2019 Nov 1;127(5):1338-1348. Epub 2019 Sep 23 doi: 10.1152/japplphysiol.00452.2019. PMID: 31545156
Choudhury SR, Babes L, Rahn JJ, Ahn BY, Goring KR, King JC, Lau A, Petri B, Hao X, Chojnacki AK, Thanabalasuriar A, McAvoy EF, Tabariès S, Schraeder C, Patel KD, Siegel PM, Kopciuk KA, Schriemer DC, Muruve DA, Kelly MM, Yipp BG, Kubes P, Robbins SM, Senger DL
Cell 2019 Aug 22;178(5):1205-1221.e17. doi: 10.1016/j.cell.2019.07.017. PMID: 31442408
Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen TC, Okhuysen-Cawley RS, Relvas MS, Rozenfeld RA, Skippen PW, Stojadinovic BJ, Williams EA, Yeh TS, Balamuth F, Brierley J, de Caen AR, Cheifetz IM, Choong K, Conway E Jr, Cornell T, Doctor A, Dugas MA, Feldman JD, Fitzgerald JC, Flori HR, Fortenberry JD, Graciano AL, Greenwald BM, Hall MW, Han YY, Hernan LJ, Irazuzta JE, Iselin E, van der Jagt EW, Jeffries HE, Kache S, Katyal C, Kissoon N, Kon AA, Kutko MC, MacLaren G, Maul T, Mehta R, Odetola F, Parbuoni K, Paul R, Peters MJ, Ranjit S, Reuter-Rice KE, Schnitzler EJ, Scott HF, Torres A Jr, Weingarten-Arams J, Weiss SL, Zimmerman JJ, Zuckerberg AL
Crit Care Med 2017 Jun;45(6):1061-1093. doi: 10.1097/CCM.0000000000002425. PMID: 28509730
Bennett ML, Bennett FC, Liddelow SA, Ajami B, Zamanian JL, Fernhoff NB, Mulinyawe SB, Bohlen CJ, Adil A, Tucker A, Weissman IL, Chang EF, Li G, Grant GA, Hayden Gephart MG, Barres BA
Proc Natl Acad Sci U S A 2016 Mar 22;113(12):E1738-46. Epub 2016 Feb 16 doi: 10.1073/pnas.1525528113. PMID: 26884166Free PMC Article

Clinical prediction guides

Jakobsson G, Papareddy P, Andersson H, Mulholland M, Bhongir R, Ljungcrantz I, Engelbertsen D, Björkbacka H, Nilsson J, Manea A, Herwald H, Ruiz-Meana M, Rodríguez-Sinovas A, Chew M, Schiopu A
Crit Care 2023 Sep 29;27(1):374. doi: 10.1186/s13054-023-04652-x. PMID: 37773186Free PMC Article
Rungratanawanich W, Lin Y, Wang X, Kawamoto T, Chidambaram SB, Song BJ
Redox Biol 2023 Feb;59:102577. Epub 2022 Dec 13 doi: 10.1016/j.redox.2022.102577. PMID: 36528936Free PMC Article
Cho YE, Kim DK, Seo W, Gao B, Yoo SH, Song BJ
Hepatology 2021 Jun;73(6):2180-2195. Epub 2019 May 31 doi: 10.1002/hep.30652. PMID: 30959577Free PMC Article
Patel AA, Zhang Y, Fullerton JN, Boelen L, Rongvaux A, Maini AA, Bigley V, Flavell RA, Gilroy DW, Asquith B, Macallan D, Yona S
J Exp Med 2017 Jul 3;214(7):1913-1923. Epub 2017 Jun 12 doi: 10.1084/jem.20170355. PMID: 28606987Free PMC Article
Boutagy NE, McMillan RP, Frisard MI, Hulver MW
Biochimie 2016 May;124:11-20. Epub 2015 Jun 29 doi: 10.1016/j.biochi.2015.06.020. PMID: 26133659Free PMC Article

Recent systematic reviews

Tipa RO, Balan DG, Georgescu MT, Ignat LA, Vacaroiu IA, Georgescu DE, Raducu L, Mihai DA, Chiperi LV, Balcangiu-Stroescu AE
Int J Mol Sci 2024 May 2;25(9) doi: 10.3390/ijms25094972. PMID: 38732190Free PMC Article
Silva JSC, Seguro CS, Naves MMV
Nutr Metab Cardiovasc Dis 2022 Apr;32(4):863-877. Epub 2022 Jan 29 doi: 10.1016/j.numecd.2022.01.023. PMID: 35227549
Zhang HY, Tian JX, Lian FM, Li M, Liu WK, Zhen Z, Liao JQ, Tong XL
Biomed Pharmacother 2021 Jan;133:110857. Epub 2020 Nov 13 doi: 10.1016/j.biopha.2020.110857. PMID: 33197760
Malik F, Mehdi SF, Ali H, Patel P, Basharat A, Kumar A, Ashok F, Stein J, Brima W, Malhotra P, Roth J
Diabetes Metab Res Rev 2018 May;34(4):e2975. Epub 2018 Feb 20 doi: 10.1002/dmrr.2975. PMID: 29271563
Gomes JMG, Costa JA, Alfenas RCG
Metabolism 2017 Mar;68:133-144. Epub 2016 Dec 18 doi: 10.1016/j.metabol.2016.12.009. PMID: 28183445

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